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Anti-SMARCB1 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-SMARCB1 Antibody

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Overview

Name:	Anti-SMARCB1 Antibody See all SMARCB1 primary antibodies
Description:	Rabbit polyclonal antibody to SMARCB1
Specificity:	The antibody detects endogenous levels of total SMARCB1 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein of human SMARCB1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.6mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their ***** state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.
Involvement in Disease:	Rhabdoid tumor predisposition syndrome 1: A familial cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the most aggressive and lethal malignancies occurring in early childhood. Schwannomatosis 1: A cancer syndrome in which patients develop multiple non-vestibular schwannomas, benign neoplasms that arise from Schwann cells of the cranial, peripheral, and autonomic nerves. Coffin-Siris syndrome 3: A form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported.
Sequence Similarities:	Belongs to the SNF5 family.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 6598?Human Omim: 601607?Human SwissProt: Q12824?Human Unigene: 534350?Human
Synonyms:	BAF47 Antibody BRG1-associated factor 47 Antibody hSNF5 Antibody INI1 Antibody Integrase interactor 1 protein Antibody Malignant rhabdoid tumor suppressor Antibody RDT Antibody RTPS1 Antibody Sfh1p Antibody SMARCB1 Antibody SNF5 Antibody SNF5 homolog Antibody SNF5L1 Antibody SNF5_HUMAN Antibody Snr1 Antibody Sucrose nonfermenting yeast homolog like 1 Antibody SWI/SNF complex component SNF5 Antibody SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Antibody SWI10 Antibody Transcription factor TYE4 Antibody Transcription regulatory protein SNF5 Antibody TYE4 Antibody
Information:	Target information shown above is from the UniProt Consortium.