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Anti-SMARCA4 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-SMARCA4 Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-SMARCA4 Antibody See all SMARCA4 primary antibodies
Description:	Rabbit polyclonal antibody to SMARCA4
Specificity:	SMARCA4 pAb detects endogenous levels of SMARCA4 protein.
Applications:	WB, IHC, IF, IP
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human SMARCA4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 220 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their ***** state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1.
Tissue Specificity:	Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level).
Involvement in Disease:	Rhabdoid tumor predisposition syndrome 2: A familial cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the most aggressive and lethal malignancies occurring in early childhood. Coffin-Siris syndrome 4: A form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported.
Sequence Similarities:	Belongs to the SNF2/RAD54 helicase family.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 6597?Human Entrez Gene: 20586?Mouse Entrez Gene: 171379?Rat Omim: 603254?Human SwissProt: P51532?Human SwissProt: Q3TKT4?Mouse SwissProt: Q8K1P7?Rat Unigene: 327527?Human Unigene: 286593?Mouse Unigene: 23417?Rat
Synonyms:	ATP dependent helicase SMARCA4 Antibody ATP-dependent helicase SMARCA4 Antibody BAF 190 Antibody BAF190 Antibody BAF190A Antibody Brahma protein like 1 Antibody BRG1 Antibody BRG1 associated factor 190A Antibody BRG1 protein Antibody BRG1-associated factor 190A Antibody BRM/SWI2 related gene 1 Antibody Global transcription activator homologous sequence Antibody global transcription activator snf2l4 Antibody Homeotic gene regulator Antibody hSNF2b Antibody Mitotic growth and transcription activator Antibody MRD16 Antibody Nuclear protein GRB1 Antibody Protein brahma homolog 1 Antibody Protein BRG-1 Antibody Protein BRG1 Antibody RTPS2 Antibody SMARC A4 Antibody SMARCA4 Antibody SMCA4_HUMAN Antibody SNF2 Antibody SNF2 beta Antibody SNF2 like 4 Antibody SNF2-beta Antibody SNF2B Antibody SNF2L4 Antibody SNF2LB Antibody Sucrose nonfermenting like 4 Antibody SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4 Antibody SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Antibody SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 Antibody SWI2 Antibody Transcription activator BRG1 Antibody
Information:	Target information shown above is from the UniProt Consortium.