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Anti-Siah-1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Siah-1 Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Siah-1 Antibody See all Siah-1 primary antibodies
Description:	Rabbit polyclonal antibody to Siah-1
Specificity:	Siah-1 pAb detects endogenous levels of Siah-1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human Siah-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 40 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), the cell-surface receptor-type tyrosine kinase FLT3, the cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3. Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.
Tissue Specificity:	Widely expressed at a low level. Down-regulated in advanced hepatocellular carcinomas.
Sequence Similarities:	Belongs to the SINA (Seven in absentia) family.
Post-Translational Modification:	Phosphorylated on Ser-19 by ATM and ATR. This phosphorylation disrupts SIAH1 interaction with HIPK2, and subsequent proteasomal degradation of HIPK2.
Cellular Location:	Cytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear.
Database Links:	Entrez Gene: 6477?Human Entrez Gene: 20437?Mouse Entrez Gene: 140941?Rat Omim: 602212?Human SwissProt: Q8IUQ4?Human SwissProt: P61092?Mouse SwissProt: Q920M9?Rat Unigene: 706828?Human Unigene: 713615?Human Unigene: 73937?Rat
Synonyms:	E3 ubiquitin-protein ligase SIAH1 Antibody FLJ08065 Antibody hSIAH1 Antibody HUMSIAH Antibody Seven in absentia homolog 1 Antibody Seven in absentia homolog 1 (Drosophila) Antibody Siah 1 Antibody Siah 1a Antibody Siah E3 ubiquitin protein ligase 1 Antibody Siah-1 Antibody Siah-1a Antibody SIAH1 Antibody SIAH1A Antibody SIAH1_HUMAN Antibody Ubiquitin ligase SIAH1 Antibody
Information:	Target information shown above is from the UniProt Consortium.