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Anti-SHP-2 (phospho-Y580) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-SHP-2 (phospho-Y580) Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-SHP-2 (phospho-Y580) Antibody See all SHP-2 primary antibodies
Description:	Rabbit polyclonal antibody to SHP-2 (phospho-Y580)
Specificity:	p-SHP-2 (Y580) pAb detects endogenous levels of SHP-2 protein only when phosphorylated at Tyr580
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human SHP-2 around the phosphorylation site of Tyrosine 580.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 70 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
Tissue Specificity:	Widely expressed, with highest levels in heart, brain, and skeletal muscle.
Involvement in Disease:	LEOPARD syndrome 1: A disorder characterized by lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and sensorineural deafness. Noonan syndrome 1: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. Some patients with NS1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villonodular synovitis (PVNS) when occurring in the jaw or joints. Leukemia, juvenile myelomonocytic: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Metachondromatosis: A skeletal disorder with radiologic features of both multiple exostoses and Ollier disease, characterized by the presence of exostoses, commonly of the bones of the hands and feet, and enchondromas of the metaphyses of long bones and iliac crest.
Sequence Similarities:	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Post-Translational Modification:	Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 5781?Human Entrez Gene: 19247?Mouse Entrez Gene: 25622?Rat Omim: 176876?Human SwissProt: Q06124?Human SwissProt: P35235?Mouse SwissProt: P41499?Rat Unigene: 506852?Human Unigene: 474046?Mouse Unigene: 8681?Mouse Unigene: 98209?Rat
Synonyms:	BPTP3 Antibody CFC Antibody JMML Antibody METCDS Antibody MGC14433 Antibody NS1 Antibody OTTHUMP00000166107 Antibody OTTHUMP00000166108 Antibody Protein tyrosine phosphatase 2 Antibody Protein tyrosine phosphatase 2C Antibody Protein tyrosine phosphatase non receptor type 11 Antibody Protein-tyrosine phosphatase 1D Antibody Protein-tyrosine phosphatase 2C Antibody PTN11_HUMAN Antibody PTP-1D Antibody PTP-2C Antibody PTP1D Antibody PTP2C Antibody PTPN11 Antibody SAP2 Antibody SH-PTP2 Antibody SH-PTP3 Antibody SH2 domain containing protein tyrosine phosphatase 2 Antibody SHP 2 Antibody SHP-2 Antibody SHP2 Antibody SHPTP2 Antibody SHPTP3 Antibody Syp Antibody Tyrosine-protein phosphatase non-receptor type 11 Antibody
Information:	Target information shown above is from the UniProt Consortium.