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Anti-SHP-1 (K530) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-SHP-1 (K530) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SHP-1 (K530) Antibody See all SHP-1 primary antibodies
Description:	Rabbit polyclonal antibody to SHP-1 (K530)
Specificity:	SHP-1 (K530) pAb detects endogenous levels of SHP-1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 500-550 of Human SHP-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 68 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Target

Function:	Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Tissue Specificity:	Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Sequence Similarities:	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Post-Translational Modification:	Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.
Cellular Location:	Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.
Database Links:	Entrez Gene: 8431?Human Entrez Gene: 23957?Mouse Entrez Gene: 117274?Rat Omim: 604630?Human SwissProt: Q15466?Human SwissProt: Q62227?Mouse SwissProt: P97947?Rat Unigene: 427055?Human Unigene: 346759?Mouse Unigene: 10712?Rat
Synonyms:	NR0B2 Antibody Nr0b2a Antibody NR0B2_HUMAN Antibody Nuclear receptor subfamily 0 group B member 2 Antibody Nuclear receptor subfamily 0, group B, member 2a Antibody Orphan nuclear receptor SHP Antibody SHP Antibody SHP-1 Antibody Shp1 Antibody Small heterodimer partner Antibody
Information:	Target information shown above is from the UniProt Consortium.