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Anti-SHP-1 (Ab-536) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-SHP-1 (Ab-536) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SHP-1 (Ab-536) Antibody See all SHP-1 primary antibodies
Description:	Rabbit polyclonal antibody to SHP-1 (Ab-536)
Specificity:	The antibody detects endogenous level of total SHP-1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse
Immunogen:	Peptide sequence around aa.534~538 (S-E-Y-G-N) derived from Human SHP-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Tissue Specificity:	Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Sequence Similarities:	Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Post-Translational Modification:	Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity.
Cellular Location:	Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.
Database Links:	Entrez Gene: 8431?Human Entrez Gene: 23957?Mouse Omim: 604630?Human SwissProt: Q15466?Human SwissProt: Q62227?Mouse Unigene: 427055?Human Unigene: 346759?Mouse
Synonyms:	NR0B2 Antibody Nr0b2a Antibody NR0B2_HUMAN Antibody Nuclear receptor subfamily 0 group B member 2 Antibody Nuclear receptor subfamily 0, group B, member 2a Antibody Orphan nuclear receptor SHP Antibody SHP Antibody SHP-1 Antibody Shp1 Antibody Small heterodimer partner Antibody
Information:	Target information shown above is from the UniProt Consortium.