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Anti-SH2D1A Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-SH2D1A Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SH2D1A Antibody See all SH2D1A primary antibodies
Description:	Goat polyclonal antibody to SH2D1A.
Applications:	ELISA, WB, IP
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human SH2D1A (internal region).
Sequence:	C-QYPVEKKSSARSTQ
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Tissue Specificity:	Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
Involvement in Disease:	Lymphoproliferative syndrome, X-linked, 1: A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 4068?Human Omim: 300490?Human SwissProt: O60880?Human Unigene: 349094?Human
Synonyms:	DSHP Antibody Duncan disease SH2 protein Antibody Duncan disease SH2-protein Antibody EBVS Antibody IMD5 Antibody LYP Antibody MTCP1 Antibody SAP Antibody SAP/SH2D1A Antibody SH2 domain containing 1A Antibody SH2 domain protein 1A Antibody SH2 domain-containing protein 1A Antibody SH21A_HUMAN Antibody SH2D1A Antibody SH2D1A/SAP Antibody Signaling lymphocyte activation molecule associated protein Antibody Signaling lymphocytic activation molecule-associated protein Antibody SLAM associated protein Antibody SLAM associated protein/SH2 domain protein 1A Antibody SLAM-associated protein Antibody T cell signal transduction molecule SAP Antibody T-cell signal transduction molecule SAP Antibody XLP Antibody XLPD Antibody
Information:	Target information shown above is from the UniProt Consortium.