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Anti-SFRP4 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-SFRP4 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SFRP4 Antibody See all SFRP4 primary antibodies
Description:	Rabbit polyclonal antibody to SFRP4.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human SFRP4.
Protein Length:	346
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of ***** uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
Tissue Specificity:	Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).
Involvement in Disease:	Pyle disease: A disorder characterized by cortical-bone thinning, limb deformity, bone fragility and fractures.
Sequence Similarities:	Belongs to the secreted frizzled-related protein (sFRP) family.
Cellular Location:	Secreted. Cytoplasmic in ovarian tumor cells.
Database Links:	Entrez Gene: 6424?Human Entrez Gene: 20379?Mouse Entrez Gene: 89803?Rat Omim: 606570?Human SwissProt: Q6FHJ7?Human SwissProt: Q9Z1N6?Mouse SwissProt: Q9JLS4?Rat Unigene: 658169?Human Unigene: 10788?Rat
Synonyms:	Frizzled protein Antibody Frizzled protein human endometrium Antibody FRP 4 Antibody FRP4 Antibody FrpHE Antibody human endometrium Antibody PYL Antibody Secreted frizzled-related protein 4 Antibody sFRP-4 Antibody SFRP4 Antibody SFRP4_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.