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Anti-SENP1 (D2) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-SENP1 (D2) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SENP1 (D2) Antibody See all SENP1 primary antibodies
Description:	Rabbit polyclonal antibody to SENP1 (D2)
Specificity:	SENP1 (D2) pAb detects endogenous levels of SENP1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to the N-terminual of Human SENP1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 73 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).
Tissue Specificity:	Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Sequence Similarities:	Belongs to the peptidase C48 family.
Cellular Location:	Nucleus. Cytoplasm. Shuttles between cytoplasm and nucleus.
Database Links:	Entrez Gene: 29843?Human Entrez Gene: 223870?Mouse Omim: 612157?Human SwissProt: Q9P0U3?Human SwissProt: P59110?Mouse Unigene: 603289?Human Unigene: 384023?Mouse
Synonyms:	SENP 1 Antibody SENP1 Antibody SENP1_HUMAN Antibody Sentrin specific protease 1 Antibody Sentrin-specific protease 1 Antibody Sentrin/SUMO specific protease Antibody Sentrin/SUMO specific protease 1 Antibody Sentrin/SUMO specific protease SENP 1 Antibody Sentrin/SUMO specific protease SENP1 Antibody Sentrin/SUMO-specific protease SENP1 Antibody SUMO1/sentrin specific peptidase 1 Antibody SUMO1/sentrin specific protease 1 Antibody SuPr 2 Antibody SuPr2 Antibody
Information:	Target information shown above is from the UniProt Consortium.