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Anti-S100A12 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-S100A12 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-S100A12 Antibody See all S100A12 primary antibodies
Description:	Rabbit polyclonal antibody to S100A12.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human
Immunogen:	Recombinant protein of human S100A12.
Protein Length:	92
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
Tissue Specificity:	Predominantly expressed by neutrophils, monocytes and activated macrophages. Expressed by eosinophils and macrophages in asthmatic airways in regions where mast cells accumulate. Found in high concentrations in the serum of patients suffering from various inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and Kawasaki disease.
Sequence Similarities:	Belongs to the S-100 family.
Cellular Location:	Secreted. Cytoplasm. Cytoplasm > Cytoskeleton. Cell membrane. Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
Database Links:	Entrez Gene: 6283?Human Omim: 603112?Human SwissProt: P80511?Human Unigene: 19413?Human
Synonyms:	CAAF1 Antibody CAGC Antibody Calcitermin Antibody Calcium-binding protein in amniotic fluid 1 Antibody Calgranulin C Antibody Calgranulin-C Antibody Calgranulin-related protein Antibody CGRP Antibody EN RAGE Antibody EN-RAGE Antibody ENRAGE Antibody Extracellular newly identified RAGE-binding protein Antibody migration inhibitory factor-related protein 6 Antibody MRP6 Antibody Neutrophil S100 protein Antibody p6 Antibody Protein S100 A12 Antibody S100 calcium binding protein A12 Antibody S100 calcium-binding protein A12 Antibody S100 calcium-binding protein A12 (calgranulin C) Antibody S100A12 Antibody S10AC_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.