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Anti-RSPO1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-RSPO1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-RSPO1 Antibody See all RSPO1 primary antibodies
Description:	Rabbit polyclonal antibody to RSPO1.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human RSPO1.
Protein Length:	263
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Tissue Specificity:	Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen.
Involvement in Disease:	Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin.
Sequence Similarities:	Belongs to the R-spondin family.
Cellular Location:	Secreted. Nucleus. Seems to mainly localize to nucleoli.
Database Links:	Entrez Gene: 284654?Human Entrez Gene: 192199?Mouse Entrez Gene: 313589?Rat Omim: 609595?Human SwissProt: Q2MKA7?Human SwissProt: Q9Z132?Mouse Unigene: 135015?Human Unigene: 42202?Mouse
Synonyms:	CRISTIN3 Antibody FLJ40906 Antibody hRspo1 Antibody R spondin homolog Antibody R spondin homolog (Xenopus laevis) Antibody R spondin1 Antibody R-spondin-1 Antibody Roof plate specific spondin Antibody Roof plate-specific spondin-1 Antibody RP11-566C13.1 Antibody RSPO Antibody RSPO1 Antibody RSPO1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.