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Anti-Wnt5a Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-Wnt5a Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Wnt5a Antibody See all Wnt5a primary antibodies
Description:	Rabbit polyclonal antibody to Wnt5a
Specificity:	The antibody detects endogenous level of total Wnt5a antibody.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human Wnt5a.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
Tissue Specificity:	Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
Involvement in Disease:	Robinow syndrome, autosomal dominant 1: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.
Sequence Similarities:	Belongs to the Wnt family.
Post-Translational Modification:	Glycosylation is necessary for secretion but not for activity.
Cellular Location:	Secreted > Extracellular space > Extracellular matrix.
Database Links:	Entrez Gene: 7474?Human Entrez Gene: 22418?Mouse Entrez Gene: 64566?Rat Omim: 164975?Human SwissProt: P41221?Human SwissProt: P22725?Mouse SwissProt: Q9QXQ7?Rat Unigene: 643085?Human Unigene: 287544?Mouse Unigene: 48749?Rat
Synonyms:	hWNT 5A Antibody hWNT5A Antibody Protein Wnt 5a Antibody Protein Wnt-5a Antibody Protein Wnt5a Antibody Wingless type MMTV integration site family member 5A Antibody Wnt 5a Antibody WNT 5A protein Antibody WNT 5A protein precursor Antibody Wnt5a Antibody WNT5A protein precursor Antibody WNT5A_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.