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Anti-WNT1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-WNT1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-WNT1 Antibody See all WNT1 primary antibodies
Description:	Rabbit polyclonal antibody to WNT1.
Applications:	WB
Dilutions:	WB: 1:1000 - 1:4000.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human WNT1.
Protein Length:	370
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.
Involvement in Disease:	Osteoporosis: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. Osteogenesis imperfecta 15: An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI15 is characterized by early-onset recurrent fractures, bone deformity, significant reduction of bone density, short stature, and, in some patients, blue sclerae. Tooth development and hearing are normal. Learning and developmental delays and brain anomalies have been observed in some patients.
Sequence Similarities:	Belongs to the Wnt family.
Post-Translational Modification:	Palmitoleylation is required for efficient binding to frizzled receptors. Palmitoleylation is necessary for proper trafficking to cell surface (Probable). Depalmitoleylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).
Cellular Location:	Secreted > Extracellular space > Extracellular matrix.
Database Links:	Entrez Gene: 7471?Human Entrez Gene: 22408?Mouse Entrez Gene: 24881?Rat Omim: 164820?Human SwissProt: P04628?Human SwissProt: P04426?Mouse Unigene: 248164?Human Unigene: 1123?Mouse
Synonyms:	BMND16 Antibody INT1 Antibody OI15 Antibody oncogene Int1 Antibody Proto oncogene protein Wnt 1 Antibody Proto-oncogene Int-1 homolog Antibody Proto-oncogene Wnt-1 Antibody Wingless type MMTV integration site family member 1 Antibody wingless-type MMTV integration site family, member 1 (oncogene INT1) Antibody Wnt 1 Antibody Wnt1 Antibody WNT1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.