天天爱天天透天天添,99视频综合在线播放6

您好，歡迎來(lái)到拜力生物網(wǎng)站！請(qǐng)登錄注冊(cè)

我的訂單 | 聯(lián)系我們 | 在線客服QQ：3012681483 | 客服電話：400-968-7988 | 工作時(shí)間：08:30-17:30

主營(yíng)產(chǎn)品： ELISA試劑盒、抗體、補(bǔ)體血清、兔補(bǔ)體、干擾素、小鼠測(cè)溫儀、進(jìn)口試劑、Quidel代理、Swant代理、PBL Assay Science代理

網(wǎng)站首頁(yè) 產(chǎn)品中心代理品牌新聞資訊資源中心關(guān)于我們

所在位置：首頁(yè) > 產(chǎn)品中心 > Antibodies > Antibodies產(chǎn)品

訂購(gòu)信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-WNK2 Antibody

品牌：Antibodies

貨號(hào)：

規(guī)格：50μl

貨期：

應(yīng)用：

咨詢客服

立即購(gòu)買(mǎi) 加入購(gòu)物車

Anti-WNK2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-WNK2 Antibody See all WNK2 primary antibodies
Description:	Rabbit polyclonal antibody to WNK2
Specificity:	WNK2 pAb detects endogenous levels of WNK2 protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human WNK2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 243 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
Tissue Specificity:	Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Post-Translational Modification:	Autophosphorylated.
Cellular Location:	Cytoplasm. Cell membrane.
Database Links:	Entrez Gene: 65268?Human Entrez Gene: 75607?Mouse Entrez Gene: 306811?Rat Omim: 606249?Human SwissProt: Q9Y3S1?Human SwissProt: Q3UH66?Mouse Unigene: 522291?Human Unigene: 342723?Mouse Unigene: 30163?Rat
Synonyms:	Antigen NY-CO-43 Antibody KIAA1760 Antibody mitogen-activated protein kinase kinase kinase Antibody NY CO 43 Antibody P/OKcl.13 Antibody PRKWNK2 Antibody Protein kinase lysine deficient 2 Antibody Protein kinase with no lysine 2 Antibody SDCCAG43 Antibody Serine/Threonine protein kinase WNK2 Antibody Serologically defined colon cancer antigen 43 Antibody WNK lysine deficient protein kinase 2 Antibody WNK2 Antibody
Information:	Target information shown above is from the UniProt Consortium.