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Anti-WNK1 (Y52) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-WNK1 (Y52) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-WNK1 (Y52) Antibody See all WNK1 primary antibodies
Description:	Rabbit polyclonal antibody to WNK1 (Y52)
Specificity:	WNK1 (Y52) pAb detects endogenous levels of WNK1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 20-68 of Human WNK1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 230 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
Tissue Specificity:	Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific and specifically expressed in the distal convoluted tubule (DCT) and connecting tubule (CNT) of the nephron.
Involvement in Disease:	Pseudohypoaldosteronism 2C: An autosomal dominant disorder characterized by severe hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis in some cases, and correction of physiologic abnormalities by thiazide diuretics. Neuropathy, hereditary sensory and autonomic, 2A: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN2A is an autosomal recessive disorder characterized by impairment of pain, temperature and touch sensation, onset of symptoms in infancy or early childhood, occurrence of distal extremity pathologies (paronychia, whitlows, ulcers, and Charcot joints), frequent amputations, sensory loss that affects all modalities of sensation (lower and upper limbs and perhaps the trunk as well), absence or diminution of tendon reflexes (usually in all limbs), minimal autonomic dysfunction, absence of sensory nerve action potentials, and virtual absence of myelinated fibers with decreased numbers of unmyelinated fibers in sural nerves.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Post-Translational Modification:	O-glycosylated.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 65125?Human Entrez Gene: 232341?Mouse Entrez Gene: 116477?Rat Omim: 605232?Human SwissProt: Q9H4A3?Human SwissProt: P83741?Mouse SwissProt: Q9JIH7?Rat Unigene: 744906?Human Unigene: 333349?Mouse Unigene: 27409?Rat
Synonyms:	Erythrocyte 65 kDa protein Antibody HSAN2 Antibody HSN2 Antibody hWNK1 Antibody KDP Antibody KIAA0344 Antibody Kinase deficient protein Antibody MGC163339 Antibody MGC163341 Antibody p65 Antibody PPP1R167 Antibody PRKWNK1 Antibody Prostate derived sterile 20 like kinase Antibody Protein kinase lysine deficient 1 Antibody Protein kinase lysine-deficient 1 Antibody Protein kinase with no lysine 1 Antibody Protein phosphatase 1, regulatory subunit 167 Antibody PSK Antibody Serine/threonine protein kinase WNK1 Antibody Serine/threonine protein kinase WNK1 1 Antibody Serine/threonine protein kinase WNK1 2 Antibody Serine/threonine-protein kinase WNK1 Antibody With no K Antibody WNK lysine deficient protein kinase 1 Antibody WNK lysine deficient protein kinase 1 isoform Antibody WNK1 Antibody WNK1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.