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Anti-WDR45 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-WDR45 Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-WDR45 Antibody See all WDR45 primary antibodies
Description:	Rabbit polyclonal antibody to WDR45.
Applications:	WB, IF
Dilutions:	WB: 1:500 - 1:2000, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human WDR45.
Protein Length:	360
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.
Tissue Specificity:	Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors.
Involvement in Disease:	Neurodegeneration with brain iron accumulation 5: A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. NBIA5 is characterized by global developmental delay in early childhood that is essentially static, with slow motor and cognitive gains until adolescence or early ***hood. In young ***hood, affected individuals develop progressive dystonia, parkinsonism, extrapyramidal signs, and dementia resulting in severe disability.
Sequence Similarities:	Belongs to the WD repeat SVP1 family.
Database Links:	Entrez Gene: 11152?Human Entrez Gene: 54636?Mouse Omim: 300526?Human SwissProt: Q9Y484?Human SwissProt: Q91VM3?Mouse Unigene: 632807?Human Unigene: 305725?Mouse
Synonyms:	JM5 Antibody NBIA4 Antibody WD repeat containing protein 45 Antibody WD repeat domain 45 Antibody WD repeat domain phosphoinositide interacting protein 4 Antibody WD repeat domain, X linked 1 Antibody WD45 repeat protein interacting with phosphoinositides 4 Antibody WDR45 Antibody WDRX1 Antibody WDRXI4 Antibody WIPI 4 Antibody WIPI-4 Antibody WIPI4 Antibody
Information:	Target information shown above is from the UniProt Consortium.