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Anti-WDFY2 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-WDFY2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-WDFY2 Antibody See all WDFY2 primary antibodies
Description:	Rabbit polyclonal antibody to WDFY2.
Applications:	WB
Dilutions:	WB: 1:500 - 1:2000.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human WDFY2.
Protein Length:	400
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By similarity). Participates in transferrin receptor endocytosis (PubMed:16873553).
Cellular Location:	Endosome. Early endosome. Cytoplasm. Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity).
Database Links:	Entrez Gene: 115825?Human Entrez Gene: 268752?Mouse Omim: 610418?Human SwissProt: Q96P53?Human SwissProt: Q8BUB4?Mouse Unigene: 208550?Human Unigene: 482243?Mouse
Synonyms:	PROF Antibody Propeller-FYVE protein Antibody RP11 147H23.1 Antibody WD repeat and FYVE domain containing 2 Antibody WD repeat and FYVE domain-containing protein 2 Antibody WD40 and FYVE domain containing 2 Antibody WD40- and FYVE domain-containing protein 2 Antibody WDF2 Antibody WDFY2 Antibody WDFY2_HUMAN Antibody ZFYVE22 Antibody Zinc finger FYVE domain-containing protein 22 Antibody
Information:	Target information shown above is from the UniProt Consortium.