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Anti-WBP7 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-WBP7 Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-WBP7 Antibody See all WBP7 primary antibodies
Description:	Rabbit polyclonal antibody to WBP7
Specificity:	WBP7 pAb detects endogenous levels of WBP7 protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human WBP7.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 36, 294 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.
Tissue Specificity:	Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas. Often amplified in pancreatic carcinomas.
Sequence Similarities:	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 9757?Human Entrez Gene: 75410?Mouse Entrez Gene: 102550344?Rat Omim: 606834?Human SwissProt: Q9UMN6?Human SwissProt: O08550?Mouse Unigene: 676457?Human Unigene: 92236?Human Unigene: 168688?Mouse
Synonyms:	Histone-lysine N-methyltransferase 2B Antibody HRX2 Antibody KIAA0304 gene product Antibody KMT2B Antibody KMT2B / MLL4 Antibody KMT2B_HUMAN Antibody Likely ortholog of mouse WW domain binding protein 7 Antibody Lysine N-methyltransferase 2B Antibody mixed lineage leukemia 4 Antibody Mixed lineage leukemia gene homolog 2 protein Antibody MLL2 Antibody myeloid lymphoid leukemia 4 Antibody Myeloid lymphoid or mixed lineage leukemia protein 4 Antibody Myeloid/lymphoid or mixed-lineage leukemia protein 4 Antibody Trithorax homolog 2 Antibody trithorax homologue 2 Antibody TRX2 Antibody WBP-7 Antibody WBP7 Antibody WW domain-binding protein 7 Antibody
Information:	Target information shown above is from the UniProt Consortium.