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Anti-VTCN1 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-VTCN1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-VTCN1 Antibody See all VTCN1 primary antibodies
Description:	Rabbit polyclonal antibody to VTCN1.
Applications:	WB
Dilutions:	WB: 1:200 - 1:2000.
Reactivity:	Human
Immunogen:	A synthetic peptide of human VTCN1.
Protein Length:	282
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
Tissue Specificity:	Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Sequence Similarities:	Belongs to the immunoglobulin superfamily. BTN/MOG family.
Post-Translational Modification:	N-glycosylated.
Cellular Location:	Cell membrane. Expressed at the cell surface. A soluble form has also been detected.
Database Links:	Entrez Gene: 79679?Human Omim: 608162?Human SwissProt: Q7Z7D3?Human Unigene: 546434?Human
Synonyms:	B7 family member, H4 Antibody B7 H4 Antibody B7 homolog 4 Antibody B7 superfamily member 1 Antibody B7 superfamily, member 1 Antibody B7-H4 Antibody B7h.5 Antibody B7H4 Antibody B7S1 Antibody B7x Antibody BC032925 Antibody Immune costimulatory protein B7-H4 Antibody Immune costimulatory protein B7H4 Antibody MGC41287 Antibody PRO1291 Antibody Protein B7S1 Antibody RP11 229A19.4 Antibody T cell costimulatory molecule B7x Antibody T-cell costimulatory molecule B7x Antibody V set domain-containing T cell activation inhibitor 1 Antibody V-set domain-containing T-cell activation inhibitor 1 Antibody VCTN1 Antibody Vtcn1 Antibody VTCN1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.