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Anti-HFE2 Antibody

品牌：Antibodies

貨號(hào)：

規(guī)格：50μl

貨期：

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Anti-HFE2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Name:	Anti-HFE2 Antibody See all HFE2 primary antibodies
Description:	Rabbit polyclonal antibody to HFE2.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human HFE2.
Protein Length:	426
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Tissue Specificity:	Adult and fetal liver, heart, and skeletal muscle.
Involvement in Disease:	Hemochromatosis 2A: A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy.
Sequence Similarities:	Belongs to the repulsive guidance molecule (RGM) family.
Post-Translational Modification:	Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HFE2 activity in BMP signaling and thefore iron homeostasis.
Cellular Location:	Cell membrane. Also released in the extracellular space.