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Anti-HES-1 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-HES-1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-HES-1 Antibody See all HES-1 primary antibodies
Description:	Rabbit polyclonal antibody to HES-1
Specificity:	Not yet tested in other species.
Applications:	ELISA, WB
Reactivity:	Human, Mouse, Rat
Immunogen:	15 amino acid peptide from near the N terminal residues of human HES-1 protein.The peptide sequence is: CDALKKDSSRHSKLEK
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity purified
Concentration:	1.0mg / ml
Formulation:	PBS, pH 7.4 with 0.02% Sodium Azide
Storage:	This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Target

Function:	Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
Tissue Specificity:	Present in all tissues examined but highest in epithelial cells and in mesoderm-derived tissues such as embryonal muscle cells.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 3280?Human Entrez Gene: 15205?Mouse Entrez Gene: 29577?Rat Omim: 139605?Human SwissProt: Q14469?Human SwissProt: P35428?Mouse SwissProt: Q04666?Rat Unigene: 250666?Human Unigene: 390859?Mouse Unigene: 19727?Rat
Synonyms:	bHLHb39 Antibody C-HAIRY1 Antibody c-hairy1A Antibody Class B basic helix-loop-helix protein 39 Antibody FLJ20408 Antibody Hairy and enhancer of split 1 Antibody Hairy and enhancer of split 1 (Drosophila) Antibody Hairy homolog Antibody Hairy homolog (Drosophila) Antibody Hairy like Antibody Hairy, Drosophila, homolog of Antibody Hairy-like protein Antibody Hairy/enhancer of split, Drosophila, homolog of, 1 Antibody HAIRY1 Antibody HES-1 Antibody Hes1 Antibody Hes1 hairy and enhancer of split 1 (Drosophila) Antibody HES1_HUMAN Antibody HHL Antibody HL Antibody HRY Antibody MGC129109 Antibody OTTHUMP00000209031 Antibody RHL Antibody Transcription factor HES-1 Antibody
Information:	Target information shown above is from the UniProt Consortium.