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Anti-Her3 / ErbB3 (Ab-1289) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Her3 / ErbB3 (Ab-1289) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Her3 / ErbB3 (Ab-1289) Antibody See all Her3 primary antibodies
Description:	Rabbit polyclonal antibody to Her3 / ErbB3 (Ab-1289)
Specificity:	The antibody detects endogenous level of total Her3 / ErbB3 protein.
Applications:	IF
Reactivity:	Human
Immunogen:	Peptide sequence around aa.1287~1291 (Q-G-Y-E-E) derived from Human Her3 / ErbB3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
Tissue Specificity:	Epithelial tissues and brain.
Involvement in Disease:	Lethal congenital contracture syndrome 2: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology.
Sequence Similarities:	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-Translational Modification:	Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 2065?Human Omim: 190151?Human SwissProt: P21860?Human Unigene: 118681?Human
Synonyms:	c erbB 3 Antibody c erbB3 Antibody Erb b2 receptor tyrosine kinase 3 Antibody ErbB 3 Antibody ERBB3 Antibody ERBB3 protein Antibody erbB3 S Antibody ERBB3_HUMAN Antibody Glial growth factor receptor Antibody HER 3 Antibody HER3 Antibody Human epidermal growth factor receptor 3 Antibody LCCS2 Antibody MDA BF 1 Antibody MGC88033 Antibody p180 ErbB3 Antibody p45 sErbB3 Antibody p85 sErbB3 Antibody proto-oncogene-like protein c ErbB 3 Antibody proto-oncogene-like protein c ErbB3 Antibody Proto-oncogene-like protein c-ErbB-3 Antibody Receptor tyrosine protein kinase erbB 3 Antibody Receptor tyrosine protein kinase erbB3 Antibody Receptor tyrosine-protein kinase erbB-3 Antibody Tyrosine kinase type cell surface receptor HER3 Antibody Tyrosine kinase-type cell surface receptor HER3 Antibody v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 Antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 Antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Antibody
Information:	Target information shown above is from the UniProt Consortium.