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Anti-HDAC9 Antibody

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Anti-HDAC9 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-HDAC9 Antibody See all HDAC9 primary antibodies
Description:	Rabbit polyclonal antibody to HDAC9
Specificity:	HDAC9 pAb detects endogenous levels of HDAC9 protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human HDAC9 .
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 117 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.6.

Target

Function:	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.
Tissue Specificity:	Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).
Sequence Similarities:	Belongs to the histone deacetylase family. HD type 2 subfamily.
Post-Translational Modification:	Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity). Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 9734?Human Entrez Gene: 687001?Rat Omim: 606543?Human SwissProt: Q9UKV0?Human Unigene: 196054?Human
Synonyms:	HD 7 Antibody HD 7B Antibody HD 9 Antibody HD7 Antibody HD7B Antibody HD9 Antibody HDAC Antibody HDAC 7 Antibody HDAC 7B Antibody HDAC 9 Antibody HDAC 9B Antibody HDAC 9FL Antibody HDAC7 Antibody HDAC7B Antibody HDAC9 Antibody HDAC9B Antibody HDAC9FL Antibody HDAC9_HUMAN Antibody HDRP Antibody Histone deacetylase 4/5 related protein Antibody Histone deacetylase 7 Antibody Histone deacetylase 7B Antibody Histone deacetylase 9 Antibody Histone deacetylase 9A Antibody Histone deacetylase related protein Antibody Histone deacetylase-related protein Antibody KIAA0744 Antibody MEF2 interacting transcription repressor MITR Antibody MEF2 interacting transcription repressor protein Antibody MEF2-interacting transcription repressor MITR Antibody MITR Antibody
Information:	Target information shown above is from the UniProt Consortium.