国产激情小说,在线一卡二卡三卡不卡

您好，歡迎來到拜力生物網站！請登錄注冊

我的訂單 | 聯(lián)系我們 | 在線客服QQ：3012681483 | 客服電話：400-968-7988 | 工作時間：08:30-17:30

主營產品： ELISA試劑盒、抗體、補體血清、兔補體、干擾素、小鼠測溫儀、進口試劑、Quidel代理、Swant代理、PBL Assay Science代理

網站首頁產品中心代理品牌新聞資訊資源中心關于我們

所在位置：首頁 > 產品中心 > Antibodies > Antibodies產品

訂購信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-HDAC7A (Phospho-Ser486) Antibody

品牌：Antibodies

貨號：

規(guī)格：50μl

貨期：

應用：

咨詢客服

立即購買加入購物車

Anti-HDAC7A (Phospho-Ser486) Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-HDAC7A (Phospho-Ser486) Antibody See all HDAC7A primary antibodies
Description:	Rabbit Polycolonal antibody to HDAC7A (Phospho-Ser486)
Specificity:	HDAC7A (Phospho-Ser486) Antibody detects endogenous levels of HDAC7A only when phosphorylated at Ser486
Applications:	WB
Reactivity:	Human, Mouse
Immunogen:	A synthesized peptide derived from human HDAC7A (Phospho-Ser486)
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).
Sequence Similarities:	Belongs to the histone deacetylase family. HD type 2 subfamily.
Post-Translational Modification:	May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.
Cellular Location:	Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
Database Links:	Entrez Gene: 51564?Human Entrez Gene: 56233?Mouse Omim: 606542?Human SwissProt: Q8WUI4?Human SwissProt: Q8C2B3?Mouse Unigene: 200063?Human Unigene: 384027?Mouse
Synonyms:	DKFZP586J0917 Antibody FLJ99588 Antibody HD 7a Antibody HD7 Antibody HD7a Antibody HDAC 7 Antibody HDAC 7A Antibody HDAC7 Antibody HDAC7A Antibody HDAC7_HUMAN Antibody Histone deacetylase 7 Antibody Histone deacetylase 7A Antibody OTTHUMP00000202813 Antibody OTTHUMP00000202814 Antibody
Information:	Target information shown above is from the UniProt Consortium.