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Anti-HDAC5 (P253) Antibody

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Anti-HDAC5 (P253) Antibody

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Overview

Name:	Anti-HDAC5 (P253) Antibody See all HDAC5 primary antibodies
Description:	Rabbit polyclonal antibody to HDAC5 (P253)
Specificity:	HDAC5 (P253) pAb detects endogenous levels of HDAC5 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide, corresponding to amino acids 220-269 of Human HDAC5.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 121 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Tissue Specificity:	Ubiquitous.
Sequence Similarities:	Belongs to the histone deacetylase family. HD type 2 subfamily.
Post-Translational Modification:	Phosphorylated by AMPK, CaMK1, SIK1 and PRKD1 at Ser-259 and Ser-498. The phosphorylation is required for the export to the cytoplasm and inhibition. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylated by GRK5, leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription (By similarity).
Cellular Location:	Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
Database Links:	Entrez Gene: 10014?Human Entrez Gene: 15184?Mouse Omim: 605315?Human SwissProt: Q9UQL6?Human SwissProt: Q9Z2V6?Mouse Unigene: 438782?Human Unigene: 22665?Mouse
Synonyms:	Antigen NY CO 9 Antibody Antigen NY-CO-9 Antibody HD5 Antibody HDAC 5 Antibody HDAC5 Antibody HDAC5_HUMAN Antibody Histone deacetylase 5 Antibody NY CO 9 Antibody
Information:	Target information shown above is from the UniProt Consortium.