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Anti-HDAC4 (phospho-S632) Antibody

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Anti-HDAC4 (phospho-S632) Antibody

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Overview

Name:	Anti-HDAC4 (phospho-S632) Antibody See all HDAC4 primary antibodies
Description:	Rabbit polyclonal antibody to HDAC4 (phospho-S632)
Specificity:	p-HDAC4 (S632) pAb detects endogenous levels of HDAC4 protein only when phosphorylated at Ser632.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human HDAC4 around the phosphorylation site of Serine 632.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 119 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Target

Function:	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).
Tissue Specificity:	Ubiquitous.
Involvement in Disease:	Brachydactyly-mental retardation syndrome: A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism.
Sequence Similarities:	Belongs to the histone deacetylase family. HD type 2 subfamily.
Post-Translational Modification:	Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues by CaMK2D is required for the interaction with 14-3-3. Phosphorylation at Ser-350, within the PxLPxI/L motif, impairs the binding of ANKRA2 but generates a high-affinity docking site for 14-3-3.
Cellular Location:	Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.
Database Links:	Entrez Gene: 9759?Human Entrez Gene: 208727?Mouse Entrez Gene: 363287?Rat Omim: 605314?Human SwissProt: P56524?Human SwissProt: Q6NZM9?Mouse SwissProt: Q99P99?Rat Unigene: 20516?Human Unigene: 318567?Mouse Unigene: 23483?Rat
Synonyms:	AHO3 Antibody BDMR Antibody EC 3.5.1.98 Antibody HA6116 Antibody HD 4 Antibody HD4 Antibody HDAC 4 Antibody HDAC A Antibody HDAC4 Antibody HDAC4_HUMAN Antibody HDACA Antibody Histone deacetylase 4 Antibody Histone Deacetylase A Antibody KIAA0288 Antibody
Information:	Target information shown above is from the UniProt Consortium.