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Anti-HDAC3 Antibody

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Anti-HDAC3 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-HDAC3 Antibody See all HDAC3 primary antibodies
Description:	Mouse monoclonal antibody to HDAC3
Applications:	E, WB
Reactivity:	Human, Canine, Rat, Rabbit, Mouse
Immunogen:	Purified recombinant human HDAC3 protein fragments expressed in E.coli.
Host:	Mouse
Clonality:	Monoclonal
Isotype:	IgG1
Conjugate:	Unconjugated
Formulation:	ascites

Target

Function:	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Contributes, together with XBP1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (By similarity).
Sequence Similarities:	Belongs to the histone deacetylase family. HD type 1 subfamily.
Cellular Location:	Nucleus. Cytoplasm. Cytoplasm > Cytosol. Colocalizes with XBP1 and AKT1 in the cytoplasm. Predominantly expressed in the nucleus in the presence of CCAR2 (By similarity).
Database Links:	Entrez Gene: 478040?Dog Entrez Gene: 8841?Human Entrez Gene: 15183?Mouse Entrez Gene: 84578?Rat Omim: 605166?Human SwissProt: O15379?Human SwissProt: O88895?Mouse SwissProt: Q6P6W3?Rat Unigene: 519632?Human Unigene: 20521?Mouse Unigene: 17284?Rat
Synonyms:	HD3 Antibody HDAC 3 Antibody HDAC3 Antibody HDAC3_HUMAN Antibody Histone deacetylase 3 Antibody RPD3 Antibody RPD3 2 Antibody RPD3-2 Antibody SMAP45 Antibody
Information:	Target information shown above is from the UniProt Consortium.