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Anti-HDAC3 (Phospho-Ser424) Antibody

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規(guī)格：50μl

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Anti-HDAC3 (Phospho-Ser424) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-HDAC3 (Phospho-Ser424) Antibody See all HDAC3 primary antibodies
Description:	Rabbit polyclonal antibody to HDAC3 (Phospho-Ser424)
Specificity:	The antibody detects endogenous level of HDAC3 only when phosphorylated at Serine 424.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of Serine 424 (K-E-S(p)-D-V) derived from Human HDAC3
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Function:	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Tissue Specificity:	Widely expressed.
Sequence Similarities:	Belongs to the histone deacetylase family. HD type 1 subfamily.
Post-Translational Modification:	Sumoylated in vitro.
Cellular Location:	Nucleus. Cytoplasm. Cytoplasm > Cytosol. Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2.
Database Links:	Entrez Gene: 8841?Human Entrez Gene: 15183?Mouse Entrez Gene: 84578?Rat Omim: 605166?Human SwissProt: O15379?Human SwissProt: O88895?Mouse SwissProt: Q6P6W3?Rat Unigene: 519632?Human Unigene: 20521?Mouse Unigene: 17284?Rat
Synonyms:	HD3 Antibody HDAC 3 Antibody HDAC3 Antibody HDAC3_HUMAN Antibody Histone deacetylase 3 Antibody RPD3 Antibody RPD3 2 Antibody RPD3-2 Antibody SMAP45 Antibody
Information:	Target information shown above is from the UniProt Consortium.