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Anti-SERPINA5 Antibody

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Anti-SERPINA5 Antibody

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Overview

Name:	Anti-SERPINA5 Antibody See all SERPINA5 primary antibodies
Description:	Rabbit polyclonal antibody to SERPINA5
Specificity:	The antibody detects endogenous levels of total SERPINA5 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to residues near the C terminal of human Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.5mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.
Tissue Specificity:	Predominantly expressed in the epithelium of seminal vesicles. Expressed in the proximal tubular epithelium of the kidney. Expressed in the superficial and more differentiated epidermal keratinocytes of the skin. Expressed in megakaryocytes and platelets. Expressed poorly in kidney tumor cells compared to non tumor kidney tissues. Expressed in spermatozoa. Present in very high concentration in seminal plasma. Present in high concentration in plasma, synovial and Graaf follicle fluids. Present in low concentration in breast milk and in amniotic fluids. Present in very low concentration in urine, cerebrospinal fluids, saliva and tears (at protein level). Strongly expressed in liver. Expressed in kidney, spleen, pancreas, skeletal muscle, heart, testes, ovary, interstitial Leydig cells, epididymal glands, seminal vesicles and prostate.
Sequence Similarities:	Belongs to the serpin family.
Post-Translational Modification:	N- and O-glycosylated. N-glycosylation consists of a mixture of sialylated bi- (including sialyl-Lewis X epitopes), tri- and tetra-antennary complex-type chains; affects the maximal heparin- and thrombomodulin-enhanced rates of thrombin inhibition. O-glycosylated with core 1 or possibly core 8 glycans. Further modified with 2 sialic acid residues.
Cellular Location:	Secreted > Extracellular space. Localized on the plasma membrane overlying the acrosomal head of spermatozoa of ependymal spermatozoa and ejaculated sperm. Localized at the equatorial segment of acrosome-reacted spematozoa. Localized in alpha granules in resting platelets and on the external plasma membrane and within the surface-connected cannalicular system in activated platelets.
Database Links:	Entrez Gene: 5104?Human Omim: 601841?Human SwissProt: P05154?Human Unigene: 159628?Human
Synonyms:	Acrosomal serine protease inhibitor Antibody IPSP Antibody IPSP_HUMAN Antibody PAI 3 Antibody PAI-3 Antibody PAI3 Antibody PCI Antibody PCI-B Antibody PLANH 3 Antibody PLANH3 Antibody Plasma serine protease inhibitor Antibody Plasminogen activator inhibitor 3 Antibody Plasminogen activator inhibitor III Antibody PROCI Antibody Protein C inhibitor Antibody Serpin A5 Antibody Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 5 Antibody Serpin peptidase inhibitor clade A member 5 Antibody Serpina5 Antibody
Information:	Target information shown above is from the UniProt Consortium.