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Anti-Septin 7 (M368) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-Septin 7 (M368) Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Septin 7 (M368) Antibody See all Septin 7 primary antibodies
Description:	Rabbit polyclonal antibody to Septin 7 (M368)
Specificity:	Septin 7 (M368) pAb detects endogenous levels of Septin 7 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 332-389 of Human Septin 7.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 51 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).
Tissue Specificity:	Widely expressed.
Sequence Similarities:	Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
Cellular Location:	Cytoplasm. Chromosome > Centromere > Kinetochore. Cytoplasm > Cytoskeleton > Spindle. Cleavage furrow. Midbody. Cytoplasm > Cytoskeleton > Cilium axoneme. Cell projection > Cilium > Flagellum. Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By similarity). Found in the sperm annulus (PubMed:25588830).
Database Links:	Entrez Gene: 989?Human Entrez Gene: 235072?Mouse Entrez Gene: 64551?Rat Omim: 603151?Human SwissProt: Q16181?Human SwissProt: O55131?Mouse SwissProt: Q9WVC0?Rat Unigene: 191346?Human Unigene: 270259?Mouse Unigene: 48701?Rat
Synonyms:	CDC10 Antibody CDC10 protein homolog Antibody CDC3 Antibody Cell division cycle 10 Antibody NBLA02942 Antibody SEPT7 Antibody SEPT7A Antibody SEPT7_HUMAN Antibody Septin 7 Antibody Septin-7 Antibody
Information:	Target information shown above is from the UniProt Consortium.