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Anti-SENP3 Antibody

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Anti-SENP3 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SENP3 Antibody See all SENP3 primary antibodies
Description:	Rabbit polyclonal antibody to SENP3
Specificity:	The antibody detects endogenous levels of total SENP3 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthesized peptide derived from Internal of human SENP3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Sequence Similarities:	Belongs to the peptidase C48 family.
Cellular Location:	Nucleus > Nucleolus. Nucleus > Nucleoplasm. Cytoplasm. Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity).
Database Links:	Entrez Gene: 26168?Human Entrez Gene: 80886?Mouse Omim: 612844?Human SwissProt: Q9H4L4?Human SwissProt: Q9EP97?Mouse Unigene: 513926?Human Unigene: 733104?Human Unigene: 284592?Mouse Unigene: 422171?Mouse
Synonyms:	SENP3 Antibody SENP3_HUMAN Antibody Sentrin / SUMO specific protease 3 Antibody Sentrin specific protease 3 Antibody Sentrin-specific protease 3 Antibody Sentrin/SUMO-specific protease SENP3 Antibody SMT3IP1 Antibody SSP3 Antibody SUMO 1 specific protease 3 Antibody SUMO-1-specific protease 3 Antibody SUMO1 specific protease 3 Antibody SUMO1/sentrin/SMT3 specific peptidase 3 Antibody SUSP3 Antibody
Information:	Target information shown above is from the UniProt Consortium.