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Anti-SEMA7A Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-SEMA7A Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SEMA7A Antibody See all SEMA7A primary antibodies
Description:	Rabbit polyclonal antibody to SEMA7A
Specificity:	The antibody detects endogenous levels of total SEMA7A protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.9mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Tissue Specificity:	Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.
Sequence Similarities:	Belongs to the semaphorin family.
Cellular Location:	Cell membrane. Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
Database Links:	Entrez Gene: 8482?Human Entrez Gene: 20361?Mouse Omim: 607961?Human SwissProt: O75326?Human SwissProt: Q9QUR8?Mouse Unigene: 24640?Human Unigene: 335187?Mouse
Synonyms:	CD 108 Antibody CD108 Antibody CD108 antigen Antibody CDw108 Antibody H Sema K1 Antibody H Sema L Antibody H-SEMA-K1 Antibody H-Sema-L Antibody JMH Antibody JMH blood group antigen Antibody John Milton Hagen blood group H Sema K1 Antibody John Milton Hargen human blood group Ag Antibody John-Milton-Hargen human blood group Ag Antibody MGC126692 Antibody MGC126696 Antibody SEM7A_HUMAN Antibody Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A Antibody Sema K1 Antibody Sema L Antibody SEMA7A Antibody SEMAK1 Antibody SEMAL Antibody Semaphorin 7a Antibody Semaphorin 7A GPI membrane anchor Antibody Semaphorin K1 Antibody Semaphorin L Antibody Semaphorin-7A Antibody Semaphorin-K1 Antibody Semaphorin-L Antibody Semaphorin7a Antibody
Information:	Target information shown above is from the UniProt Consortium.