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Anti-SEMA4A (N532) Antibody

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規(guī)格：50μl

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Anti-SEMA4A (N532) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SEMA4A (N532) Antibody See all SEMA4A primary antibodies
Description:	Rabbit polyclonal antibody to SEMA4A (N532)
Specificity:	SEMA4A (N532) pAb detects endogenous levels of SEMA4A protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 500-546 of Human SEMA4A.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 84 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).
Involvement in Disease:	Retinitis pigmentosa 35: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Cone-rod dystrophy 10: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors.
Sequence Similarities:	Belongs to the semaphorin family.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 64218?Human Entrez Gene: 20351?Mouse Entrez Gene: 310630?Rat Omim: 607292?Human SwissProt: Q9H3S1?Human SwissProt: Q62178?Mouse Unigene: 408846?Human Unigene: 439752?Mouse
Synonyms:	CORD10 Antibody RP11 54H19 2 Antibody RP35 Antibody SEM4A_HUMAN Antibody Sema B Antibody Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain 4A Antibody Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4A Antibody Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) Antibody SEMA4A Antibody SEMAB Antibody Semaphorin 4A precursor Antibody Semaphorin B Antibody Semaphorin-4A Antibody Semaphorin-B Antibody SEMB Antibody
Information:	Target information shown above is from the UniProt Consortium.