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Anti-SELPLG Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-SELPLG Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-SELPLG Antibody See all SELPLG primary antibodies
Description:	Rabbit polyclonal antibody to SELPLG.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human
Immunogen:	Recombinant protein of human SELPLG.
Protein Length:	412
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
Tissue Specificity:	Expressed on neutrophils, monocytes and most lymphocytes.
Post-Translational Modification:	Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 6404?Human Omim: 600738?Human SwissProt: Q14242?Human Unigene: 591014?Human
Synonyms:	CD 162 Antibody CD162 Antibody CD162 antigen Antibody CLA Antibody Cutaneous lymphocyte associated associated antigen Antibody P selectin glycoprotein ligand 1 Antibody P selectin glycoprotein ligand 1 precursor Antibody P-selectin glycoprotein ligand 1 Antibody PSGL 1 Antibody PSGL-1 Antibody PSGL1 Antibody Selectin P ligand Antibody SELPLG Antibody SELPL_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.