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Anti-SEK1 / MKK4 (Phospho-Thr261) Antibody

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Anti-SEK1 / MKK4 (Phospho-Thr261) Antibody

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規(guī)格：50μl

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Anti-SEK1 / MKK4 (Phospho-Thr261) Antibody

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Overview

Name:	Anti-SEK1 / MKK4 (Phospho-Thr261) Antibody See all SEK1 primary antibodies
Description:	Rabbit polyclonal antibody to SEK1 / MKK4 (Phospho-Thr261)
Specificity:	The antibody detects endogenous level of SEK1 / MKK4 only when phosphorylated at threonine 261.
Applications:	IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of threonine261 (A-K-T(p)-RD) derived from Human SEK1 / MKK4.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Tissue Specificity:	Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Sequence Similarities:	Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Post-Translational Modification:	Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks).
Cellular Location:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 6416?Human Entrez Gene: 26398?Mouse Entrez Gene: 287398?Rat Omim: 601335?Human SwissProt: P45985?Human SwissProt: P47809?Mouse Unigene: 514681?Human Unigene: 412922?Mouse
Synonyms:	c Jun N terminal kinase kinase 1 Antibody C-JUN N-terminal kinase kinase 1 Antibody Dual specificity mitogen activated protein kinase kinase 4 Antibody Dual specificity mitogen-activated protein kinase kinase 4 Antibody JNK Activated Kinase 1 Antibody JNK activating kinase 1 Antibody JNK-activating kinase 1 Antibody JNKK Antibody JNKK1 Antibody MAP kinase kinase 4 Antibody Map2k4 Antibody MAPK ERK kinase 4 Antibody MAPK/ERK kinase 4 Antibody MAPKK 4 Antibody MAPKK4 Antibody MEK 4 Antibody MEK4 Antibody Mitogen activated protein kinase kinase 4 Antibody MKK 4 Antibody MKK4 Antibody MP2K4_HUMAN Antibody PRKMK4 Antibody SAPK ERK kinase 1 Antibody SAPK/ERK kinase 1 Antibody SAPKK 1 Antibody SAPKK1 Antibody SEK1 Antibody SERK1 Antibody SKK1 Antibody Stress activated protein kinase kinase 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.