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Anti-SDHB Antibody

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Anti-SDHB Antibody

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Overview

Name:	Anti-SDHB Antibody See all SDHB primary antibodies
Description:	Rabbit polyclonal antibody to SDHB
Specificity:	The antibody detects endogenous levels of total SDHB protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.3mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Involvement in Disease:	Pheochromocytoma: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. Paragangliomas 4: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear. Paraganglioma and gastric stromal sarcoma: Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. Cowden syndrome 2: A form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid. CWS2 inheritance is autosomal dominant.
Sequence Similarities:	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
Cellular Location:	Mitochondrion inner membrane.
Database Links:	Entrez Gene: 6390?Human Entrez Gene: 67680?Mouse Omim: 185470?Human SwissProt: P21912?Human SwissProt: Q9CQA3?Mouse Unigene: 465924?Human Unigene: 246965?Mouse
Synonyms:	CWS2 Antibody DHSB_HUMAN Antibody FLJ92337 Antibody Ip Antibody Iron sulfur subunit Antibody Iron sulfur subunit of complex II Antibody Iron-sulfur subunit of complex II Antibody mitochondrial Antibody PGL 4 Antibody PGL4 Antibody SDH Antibody SDH 1 Antibody SDH1 Antibody SDH2 Antibody SDH2, homolog of Antibody SDHB Antibody SDHIP Antibody Succinate Dehydrogenase 1 Iron Sulfur Subunit Antibody Succinate Dehydrogenase 2, S. cerevisiae, homolog of Antibody Succinate dehydrogenase complex iron sulfur subunit B Antibody Succinate dehydrogenase complex subunit B iron sulfur Antibody Succinate Dehydrogenase Complex Subunit B Iron Sulfur Protein Antibody succinate dehydrogenase complex, subunit B, iron sulfur (Ip) Antibody Succinate dehydrogenase iron sulfur protein Antibody Succinate dehydrogenase [ubiquinone] iron sulfur protein mitochondrial Antibody Succinate dehydrogenase [ubiquinone] iron sulfur subunit Antibody Succinate dehydrogenase [ubiquinone] iron-sulfur subunit Antibody succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Antibody
Information:	Target information shown above is from the UniProt Consortium.