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Anti-SDHA Antibody

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Anti-SDHA Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SDHA Antibody See all SDHA primary antibodies
Description:	Rabbit polyclonal antibody to SDHA
Specificity:	SDHA pAb detects endogenous levels of SDHA protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human SDHA.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 72 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225).
Involvement in Disease:	Mitochondrial complex II deficiency: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy, muscle weakness, exercise intolerance, cardiomyopathy. Some patients manifest Leigh syndrome or Kearns-Sayre syndrome. Leigh syndrome: An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. Cardiomyopathy, dilated 1GG: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Paragangliomas 5: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.
Sequence Similarities:	Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
Post-Translational Modification:	Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation.
Cellular Location:	Mitochondrion inner membrane.
Database Links:	Entrez Gene: 6389?Human Entrez Gene: 66945?Mouse Entrez Gene: 157074?Rat Omim: 600857?Human SwissProt: P31040?Human SwissProt: Q8K2B3?Mouse SwissProt: Q920L2?Rat Unigene: 440475?Human Unigene: 158231?Mouse Unigene: 101725?Rat
Synonyms:	CMD1GG Antibody DHSA_HUMAN Antibody Flavoprotein subunit of complex II Antibody Fp Antibody PGL5 Antibody SDH 2 Antibody SDH1 Antibody SDH2 Antibody SDHA Antibody SDHF Antibody Succinate dehydrogenase complex flavoprotein subunit Antibody Succinate dehydrogenase complex flavoprotein subunit A Antibody Succinate dehydrogenase complex flavoprotein subunit precursor Antibody Succinate dehydrogenase complex subunit A Antibody Succinate dehydrogenase complex subunit A flavoprotein Antibody Succinate dehydrogenase complex subunit A flavoprotein (Fp) Antibody Succinate dehydrogenase [ubiquinone] flavoprotein subunit Antibody Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial Antibody Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Antibody
Information:	Target information shown above is from the UniProt Consortium.