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Anti-SDF-1 (M93) Antibody

品牌：Antibodies

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Anti-SDF-1 (M93) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-SDF-1 (M93) Antibody See all SDF1 primary antibodies
Description:	Rabbit polyclonal antibody to SDF-1 (M93)
Specificity:	SDF-1 (M93) pAb detects endogenous levels of SDF-1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 50-100 of Human SDF-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 10 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
Tissue Specificity:	Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.
Sequence Similarities:	Belongs to the intercrine alpha (chemokine CxC) family.
Post-Translational Modification:	Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 6387?Human Entrez Gene: 20315?Mouse Entrez Gene: 24772?Rat Omim: 600835?Human SwissProt: P48061?Human SwissProt: P40224?Mouse Unigene: 522891?Human Unigene: 303231?Mouse Unigene: 54439?Rat
Synonyms:	12-O-tetradecanoylphorbol 13-acetate repressed protein 1 Antibody AI174028 Antibody C-X-C motif chemokine 12 Antibody Chemokine (C-X-C motif) ligand 12 Antibody Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) Antibody Chemokine CXC motif ligand 12 Antibody cxcl12 Antibody hIRH Antibody hSDF-1 Antibody Intercrine reduced in hepatomas Antibody IRH Antibody OTTHUMP00000019491 Antibody PBSF Antibody Pre-B cell growth-stimulating factor Antibody SCYB12 Antibody SDF 1 Antibody SDF-1 Antibody SDF-1-alpha(3-67) Antibody SDF-1a Antibody SDF-1b Antibody SDF1 Antibody SDF1A Antibody SDF1B Antibody SDF1_HUMAN Antibody Stromal cell-derived factor 1 Antibody Stromal cell-derived factor 1 delta Antibody Stromal cell-derived factor 1 gamma Antibody Stromal cell-derived factor 1a Antibody Stromal cell-derived factor-1 alpha Antibody Thymic lymphoma cell-stimulating factor Antibody Tlsf Antibody TLSF-a Antibody TLSF-b Antibody Tlsfa Antibody Tlsfb Antibody TPAR1 Antibody
Information:	Target information shown above is from the UniProt Consortium.