Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
Function:
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
Tissue Specificity:
Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.
Sequence Similarities:
In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
Cellular Location:
Nucleus.
Database Links:
Entrez Gene: 8732?Human
Entrez Gene: 24018?Mouse
Entrez Gene: 313131?Rat
Omim: 603512?Human
SwissProt: O60942?Human
SwissProt: O55236?Mouse
Unigene: 567378?Human
Unigene: 240024?Mouse
Unigene: 464346?Mouse
Unigene: 8497?Rat
Synonyms:
CAP1A Antibody
GTase Antibody
GTP--RNA guanylyltransferase Antibody
hCAP Antibody
HCAP1 Antibody
HCE Antibody
HCE1 Antibody
MCE1 Antibody
MCE1_HUMAN Antibody
mRNA 5''-triphosphatase Antibody
mRNA capping enzyme Antibody
mRNA guanyltransferase Antibody
mRNA guanylyltransferase Antibody
Polynucleotide 5' trisphosphatase Antibody
RNA guanylyltransferase and 5' phosphatase Antibody
RNGTT Antibody
TPase Antibody
Information:
Target information shown above is from the UniProt Consortium.