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Anti-RNF31 Antibody

品牌：Antibodies

貨號：

規(guī)格：100μg

貨期：

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Anti-RNF31 Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-RNF31 Antibody See all RNF31 primary antibodies
Description:	Goat polyclonal antibody to RNF31.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human RNF31 (C terminal).
Sequence:	C-EEVPLGQSIPRRRK
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998).
Tissue Specificity:	Expressed in both normal and transformed breast epithelial cell lines.
Post-Translational Modification:	Autoubiquitinated. Interaction with OTULIN is required to prevent formation of 'Met-1'-linked polyubiquitin chains.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 55072?Human Omim: 612487?Human SwissProt: Q96EP0?Human Unigene: 375217?Human Unigene: 434081?Human
Synonyms:	E3 ubiquitin protein ligase RNF31 Antibody FLJ10111 Antibody FLJ23501 Antibody HOIL 1L interacting protein Antibody HOIL-1-interacting protein Antibody HOIL1L interacting protein Antibody HOIP Antibody RING finger protein 31 Antibody RNF31 Antibody RNF31/HOIP Antibody RNF31_HUMAN Antibody ZIBRA Antibody Zinc in between ring finger ubiquitin associated domain Antibody Zinc in-between-RING-finger ubiquitin-associated domain protein Antibody
Information:	Target information shown above is from the UniProt Consortium.