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Anti-RNF20 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-RNF20 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-RNF20 Antibody See all RNF20 primary antibodies
Description:	Rabbit polyclonal antibody to RNF20
Specificity:	The antibody detects endogenous levels of total RNF20 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to residues near the C terminal of human ring finger protein 20, E3 ubiquitin protein ligase
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.2mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
Tissue Specificity:	Expressed in the normal brain and also in malignant gliomas (at protein level).
Sequence Similarities:	Belongs to the BRE1 family.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 56254?Human Omim: 607699?Human SwissProt: Q5VTR2?Human Unigene: 729085?Human
Synonyms:	BRE1 Antibody BRE1 A Antibody BRE1 E3 ubiquitin ligase homolog Antibody BRE1-A Antibody BRE1A Antibody BRE1A_HUMAN Antibody E3 ubiquitin-protein ligase BRE1A Antibody hBRE1 Antibody Homolog of S. cerevisiae BRE1 Antibody RING finger protein 20 Antibody Ring finger protein 20 E3 ubiquitin protein ligase Antibody RNF20 Antibody
Information:	Target information shown above is from the UniProt Consortium.