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Anti-RNF2 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-RNF2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-RNF2 Antibody See all RNF2 primary antibodies
Description:	Rabbit polyclonal antibody to RNF2
Specificity:	The antibody detects endogenous level of total RNF2 protein.
Applications:	WB, IHC, IF, IP, CHIP
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human RNF2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.
Post-Translational Modification:	Polyubiquitinated in the presence of UBE2D3 (in vitro).
Cellular Location:	Nucleus. Chromosome. Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity).
Database Links:	Entrez Gene: 6045?Human Entrez Gene: 19821?Mouse Entrez Gene: 304850?Rat Omim: 608985?Human SwissProt: Q99496?Human SwissProt: Q9CQJ4?Mouse SwissProt: Q4KLY4?Rat Unigene: 591490?Human Unigene: 482250?Mouse Unigene: 19719?Rat
Synonyms:	BAP 1 Antibody BAP1 Antibody DING Antibody DinG protein Antibody E3 ubiquitin protein ligase RING 2 Antibody E3 ubiquitin protein ligase RING2 Antibody E3 ubiquitin-protein ligase RING2 Antibody HIP2 interacting protein 3 Antibody HIP2-interacting protein 3 Antibody HIPI 3 Antibody HIPI3 Antibody Huntingtin interacting protein 2 interacting protein 3 Antibody Huntingtin-interacting protein 2-interacting protein 3 Antibody OTTHUMP00000060668 Antibody Polycomb M33 interacting protein Ring 1B Antibody Polycomb M33 interacting protein Ring1B Antibody Protein DinG Antibody RING 1B Antibody RING 2 Antibody RING finger protein 1B Antibody RING finger protein 2 Antibody RING finger protein BAP 1 Antibody RING finger protein BAP-1 Antibody RING finger protein BAP1 Antibody RING1b Antibody RING2 / RING1B / RNF2 Antibody RING2_HUMAN Antibody RNF 2 Antibody Rnf2 Antibody
Information:	Target information shown above is from the UniProt Consortium.