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Anti-REL Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-REL Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-REL Antibody See all c-Rel primary antibodies
Description:	Goat polyclonal antibody to REL.
Applications:	ELISA, WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human REL (internal region).
Sequence:	NDLNASNACIYN
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 5966?Human Omim: 164910?Human SwissProt: Q04864?Human Unigene: 631886?Human
Synonyms:	Avian reticuloendotheliosis Antibody C REL Antibody C Rel protein Antibody c Rel proto oncogene protein Antibody c-Rel Antibody Oncogene REL Antibody Oncogene REL avian reticuloendotheliosis Antibody Proto-oncogene c-Rel Antibody REL Antibody REL_HUMAN Antibody v rel avian reticuloendotheliosis viral oncogene homolog Antibody v rel reticuloendotheliosis viral oncogene homolog Antibody V rel reticuloendotheliosis viral oncogene homolog (avian) Antibody
Information:	Target information shown above is from the UniProt Consortium.