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Anti-RASSF1 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-RASSF1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-RASSF1 Antibody See all RASSF1 primary antibodies
Description:	Rabbit polyclonal antibody to RASSF1
Specificity:	RASSF1 pAb detects endogenous levels of RASSF1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human RASSF1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 39 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Tissue Specificity:	Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoietic cells.
Cellular Location:	Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle. Cytoplasm > Cytoskeleton > Spindle pole. Nucleus. Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.
Database Links:	Entrez Gene: 11186?Human Entrez Gene: 56289?Mouse Entrez Gene: 363140?Rat Omim: 605082?Human SwissProt: Q9NS23?Human SwissProt: Q99MK9?Mouse Unigene: 476270?Human Unigene: 12091?Mouse Unigene: 83042?Rat
Synonyms:	123F2 Antibody Cardiac specific ras association domain family 1 protein Antibody cardiac-specific ras association domain family 1 protein, 123F2 Antibody NORE2A Antibody OTTHUMP00000195503 Antibody OTTHUMP00000195504 Antibody OTTHUMP00000195505 Antibody OTTHUMP00000195507 Antibody Pancreas specific ras association domain family 1 protein Antibody Ras association (RalGDS/AF 6) domain family member 1 Antibody Ras association domain-containing protein 1 Antibody RASF1_HUMAN Antibody RASSF1 Antibody RASSF1A Antibody RDA32 Antibody REH3P21 Antibody Tumor suppressor protein RDA32 Antibody WUGSC:H_LUCA12.5 Antibody
Information:	Target information shown above is from the UniProt Consortium.