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Anti-RANGAP1 Antibody

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規(guī)格：50μl

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Anti-RANGAP1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-RANGAP1 Antibody See all RANGAP1 primary antibodies
Description:	Rabbit polyclonal antibody to RANGAP1
Specificity:	RANGAP1 pAb detects endogenous levels of RANGAP1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human RANGAP1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~63 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Tissue Specificity:	Highly expressed in brain, thymus and testis.
Sequence Similarities:	Belongs to the RNA1 family.
Post-Translational Modification:	Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on nuclear pore complex (NPC) diassembly and during mitosis.
Cellular Location:	Cytoplasm. Nucleus membrane. Chromosome > Centromere > Kinetochore. Cytoplasm > Cytoskeleton > Spindle pole. Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
Database Links:	Entrez Gene: 5905?Human Entrez Gene: 19387?Mouse Entrez Gene: 362965?Rat Omim: 602362?Human SwissProt: P46060?Human SwissProt: P46061?Mouse Unigene: 183800?Human Unigene: 270975?Mouse Unigene: 475271?Mouse Unigene: 107099?Rat
Synonyms:	Fug 1 Antibody Fug1 Antibody GTPase-activating protein, RAN, 1 Antibody KIAA1835 Antibody MGC20266 Antibody OTTHUMP00000028918 Antibody OTTHUMP00000198755 Antibody OTTHUMP00000198756 Antibody OTTHUMP00000198757 Antibody OTTHUMP00000198758 Antibody RAGP1_HUMAN Antibody Ran 1 Antibody RAN GTPase activating protein 1 Antibody Ran GTPase-activating protein 1 Antibody Ran1 Antibody RANGAP Antibody RANGAP 1 Antibody RanGAP1 Antibody SD Antibody Segregation distorter homolog Antibody Segregation distortion Antibody
Information:	Target information shown above is from the UniProt Consortium.