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Anti-Rad51D Antibody

品牌：Antibodies

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規(guī)格：50μl

貨期：

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Anti-Rad51D Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-Rad51D Antibody See all Rad51D primary antibodies
Description:	Rabbit polyclonal antibody to Rad51D.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant Protein of human Rad51D.
Protein Length:	328
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.
Tissue Specificity:	Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes.
Involvement in Disease:	Breast-ovarian cancer, familial, 4: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.
Sequence Similarities:	Belongs to the RecA family. RAD51 subfamily.
Cellular Location:	Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Chromosome > Telomere.
Database Links:	Entrez Gene: 5892?Human Entrez Gene: 303375?Rat Omim: 602954?Human SwissProt: O75771?Human Unigene: 631757?Human Unigene: 206266?Rat
Synonyms:	BROVCA4 Antibody DNA repair protein RAD51 homolog 4 Antibody HsTRAD Antibody OTTHUMP00000163851 Antibody OTTHUMP00000163852 Antibody OTTHUMP00000163853 Antibody R51H3 Antibody RA51D_HUMAN Antibody RAD51 homolog D Antibody RAD51 homolog D (S. cerevisiae) Antibody RAD51 like 3 (S. cerevisiae) Antibody RAD51 paralog D Antibody RAD51, S. cerevisiae, homolog of, D Antibody RAD51-like protein 3 Antibody Rad51D Antibody Rad51l3 Antibody Recombination repair protein Antibody S. cerevisiae RAD51-like 3 Antibody TRAD Antibody
Information:	Target information shown above is from the UniProt Consortium.