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Anti-Rad17 (A639) Antibody

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Anti-Rad17 (A639) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Rad17 (A639) Antibody See all Rad17 primary antibodies
Description:	Rabbit polyclonal antibody to Rad17 (A639)
Specificity:	Rad17 (A639) pAb detects endogenous levels of Rad17 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 611-660 of Human Rad17.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 80 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Tissue Specificity:	Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).
Sequence Similarities:	Belongs to the rad17/RAD24 family.
Post-Translational Modification:	Phosphorylated. Phosphorylation on Ser-646 and Ser-656 is cell cycle-regulated, enhanced by genotoxic stress, and required for activation of checkpoint signaling. Phosphorylation is mediated by ATR upon UV or replication arrest, whereas it may be mediated both by ATR and ATM upon ionizing radiation. Phosphorylation on both sites is required for interaction with RAD1 but dispensable for interaction with RFC3 or RFC4.
Cellular Location:	Nucleus. Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
Database Links:	Entrez Gene: 5884?Human Entrez Gene: 19356?Mouse Entrez Gene: 310034?Rat Omim: 603139?Human SwissProt: O75943?Human SwissProt: Q6NXW6?Mouse Unigene: 16184?Human Unigene: 248489?Mouse
Synonyms:	CCYC Antibody Cell cycle checkpoint protein Antibody Cell cycle checkpoint protein RAD17 Antibody FLJ41520 Antibody HRAD 17 Antibody hRad17 Antibody R24L Antibody Rad 17 Antibody Rad 24 Antibody RAD1 (S. pombe) homolog Antibody RAD1 homolog Antibody Rad17 Antibody RAD17 homolog Antibody RAD17 homolog (S. pombe) Antibody Rad17 like protein Antibody RAD17, S. pombe, homolog of Antibody RAD17Sp Antibody RAD17_HUMAN Antibody Rad24 Antibody Rad24, mouse, homolog of Antibody Rad24, S. cerevisiae, homolog of Antibody RF C activator 1 homolog Antibody RF C/activator 1 homolog Antibody RF-C/activator 1 homolog Antibody
Information:	Target information shown above is from the UniProt Consortium.