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Anti-Rab5 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-Rab5 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-Rab5 Antibody See all Rab5 primary antibodies
Description:	Rabbit monoclonal antibody to Rab5.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:1000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human RAB5A.
Host:	Rabbit
Clonality:	Monoclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
Sequence Similarities:	Belongs to the small GTPase superfamily. Rab family.
Cellular Location:	Cell membrane. Early endosome membrane. Melanosome. Cytoplasmic vesicle. Cell projection > Ruffle. Membrane. Cytoplasm > Cytosol. Cytoplasmic vesicle > Phagosome membrane. Endosome membrane. Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable).
Database Links:	Entrez Gene: 5868?Human Entrez Gene: 271457?Mouse Entrez Gene: 64633?Rat Omim: 179512?Human SwissProt: P20339?Human SwissProt: Q9CQD1?Mouse SwissProt: M0RC99?Rat Unigene: 475663?Human Unigene: 329123?Mouse Unigene: 44477?Rat
Synonyms:	RAB 5 Antibody RAB 5A Antibody Rab5 Antibody RAB5A Antibody RAB5A member RAS oncogene family Antibody RAB5A_HUMAN Antibody RAS associated protein RAB5A Antibody Ras related protein Rab 5A Antibody Ras-related protein Rab-5A Antibody
Information:	Target information shown above is from the UniProt Consortium.