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Leptin Human

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Leptin Human

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Target

Function:	Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
Tissue Specificity:	Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
Sequence Similarities:	Belongs to the ATG5 family.
Post-Translational Modification:	Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
Cellular Location:	Cytoplasm. Preautophagosomal structure membrane. Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.
Database Links:	Entrez Gene: 9474?Human Entrez Gene: 11793?Mouse Entrez Gene: 365601?Rat Omim: 604261?Human SwissProt: Q9H1Y0?Human SwissProt: Q99J83?Mouse SwissProt: Q3MQ06?Rat Unigene: 486063?Human Unigene: 22264?Mouse Unigene: 98385?Rat
Synonyms:	APG 5 Antibody APG 5L Antibody APG5 Antibody APG5 autophagy 5 like Antibody APG5 like Antibody APG5-like Antibody APG5L Antibody APG5L/ATG5 Antibody Apoptosis specific protein Antibody Apoptosis-specific protein Antibody ASP Antibody ATG 5 Antibody Atg5 Antibody ATG5 autophagy related 5 homolog Antibody ATG5_HUMAN Antibody Autophagy protein 5 Antibody Autophagy related 5 Antibody hAPG5 Antibody Homolog of S Cerevisiae autophagy 5 Antibody OTTHUMP00000040507 Antibody
Information:	Target information shown above is from the UniProt Consortium.