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Anti-ATG16L1 Antibody

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Anti-ATG16L1 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-ATG16L1 Antibody See all ATG16L1 primary antibodies
Description:	Rabbit polyclonal antibody to ATG16L1
Specificity:	ATG16L1 pAb detects endogenous levels of ATG16L1 protein.
Applications:	WB, IHC, IF, IP
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human ATG16L1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 68 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
Involvement in Disease:	Inflammatory bowel disease 10: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Sequence Similarities:	Belongs to the WD repeat ATG16 family.
Post-Translational Modification:	Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.
Cellular Location:	Cytoplasm. Preautophagosomal structure membrane. Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme.
Database Links:	Entrez Gene: 55054?Human Entrez Gene: 77040?Mouse Entrez Gene: 363278?Rat Omim: 610767?Human SwissProt: Q676U5?Human SwissProt: Q8C0J2?Mouse Unigene: 529322?Human Unigene: 272972?Mouse Unigene: 456099?Mouse
Synonyms:	A16L1_HUMAN Antibody APG16 like 1 Antibody APG16-like 1 Antibody APG16L Antibody APG16L beta Antibody ATG16 autophagy related 16 like 1 Antibody ATG16 autophagy related 16-like 1 (S. cerevisiae) Antibody ATG16A Antibody ATG16L Antibody ATG16L1 Antibody Autophagy related protein 16 1 Antibody Autophagy-related protein 16-1 Antibody FLJ00045 Antibody FLJ10035 Antibody FLJ10828 Antibody FLJ22677 Antibody IBD10 Antibody OTTHUMP00000164391 Antibody OTTHUMP00000164393 Antibody OTTHUMP00000165876 Antibody OTTHUMP00000165877 Antibody WD repeat domain 30 Antibody WDR30 Antibody
Information:	Target information shown above is from the UniProt Consortium.